FOXO4-DRI Peptide – p53 Interaction & Cellular Senescence Research Compound
FOXO4-DRI is a synthetic D-retro-inverso (DRI) peptide studied in cellular senescence models, transcription factor signaling, and protein-protein interaction research.
It is commonly utilized in preclinical and in vitro studies involving FOXO transcription factors, p53 signaling pathways, and cellular regulatory systems.
---What is FOXO4-DRI?
FOXO4-DRI is a modified peptide derived from a functional fragment of the FOXO4 transcription factor, part of the forkhead box O (FOXO) protein family.
It incorporates a D-retro-inverso structural modification, where L-amino acids are replaced with D-amino acids to enhance peptide stability and resistance to enzymatic degradation in laboratory conditions.
---Mechanism of Action (Research-Based)
Research-based observations suggest that FOXO4-DRI may interact with cellular pathways involving transcription factor signaling and protein interaction systems in controlled experimental models.
- FOXO4–p53 Interaction: Studied in models of protein-protein binding and signaling pathways
- D-Retro-Inverso Stability: Structural modification enhances resistance to proteolytic degradation
- Transcription Factor Research: Investigated in gene regulation and signaling network models
- Cellular Senescence Models: Explored in age-related cellular process research systems
Research Applications
Cellular Senescence & Aging Research
- Senescent cell signaling pathway studies
- Cellular lifecycle and regulatory mechanism research
- Transcription factor involvement in aging models
Protein Interaction Studies
- FOXO4 and p53 interaction analysis
- Protein-protein binding mechanism research
- Transcription factor signaling pathway studies
Molecular & Cellular Biology
- Gene expression and regulatory pathway research
- Cell cycle and differentiation studies
- Comparative analysis of modified peptide structures
Product Specifications
- Product Name: FOXO4-DRI
- Type: Synthetic D-retro-inverso peptide
- Origin: Derived from FOXO4 transcription factor fragment
- Modification: L-amino acids replaced with D-amino acids
- Category: Cellular senescence & gene regulation research peptide
- Form: Lyophilized (freeze-dried) powder
- Purity: High-purity research grade (typically ≥98%)
Storage & Handling
- Store at -20°C or below for optimal stability
- Reconstitute using sterile laboratory-grade solvents
- Avoid repeated freeze-thaw cycles
- Handle under controlled laboratory conditions
Quality & Synthesis
FOXO4-DRI is synthesized using advanced peptide engineering methods, incorporating D-retro-inverso design for enhanced stability and structural consistency.
Each batch undergoes analytical validation, including HPLC and mass spectrometry, to confirm identity and suitability for laboratory research applications.
---FAQ (Structured for SEO)
What is FOXO4-DRI used for in research?
FOXO4-DRI is studied in cellular senescence models, transcription factor signaling pathways, and FOXO4-p53 interaction research in laboratory environments.
What does D-retro-inverso mean?
D-retro-inverso refers to a structural modification where L-amino acids are replaced with D-amino acids, enhancing peptide stability and resistance to degradation in experimental systems.
Is FOXO4-DRI the same as FOXO4 protein?
No. FOXO4-DRI is a modified synthetic fragment designed to mimic specific functional regions of the FOXO4 protein for research purposes.
Is FOXO4-DRI approved for human use?
No. FOXO4-DRI is strictly intended for laboratory research use only and is not approved for human consumption or medical use.
Important Disclaimer
- For research purposes only
- Not for human consumption
- Not intended to diagnose, treat, cure, or prevent any disease
- This product is strictly for laboratory research use