ACE-031 (ActRIIB-IgG1) – Myostatin Pathway Research Compound
ACE-031, also known as ActRIIB-IgG1, is a recombinant fusion protein designed for research into myostatin signaling, TGF-β pathways, and musculoskeletal biology.
It functions as a decoy receptor targeting ligands involved in muscle growth regulation, making it widely studied in skeletal muscle signaling and metabolic pathway research.
---What is ACE-031?
ACE-031 is a fusion protein combining the extracellular domain of activin receptor type IIB (ActRIIB) with an IgG1 Fc fragment. This structure enables it to bind circulating ligands and modulate signaling pathways in laboratory research models.
---Mechanism of Action (Research-Based)
Research suggests that ACE-031 may interact with members of the TGF-β superfamily, including myostatin and activins, by acting as a ligand-binding decoy receptor.
- Ligand Sequestration: Studied for binding myostatin (GDF-8) and related proteins
- TGF-β Pathway Interaction: Investigated in Smad2/3 signaling models
- ActRIIB Modulation: Explored in receptor-ligand interaction studies
- Musculoskeletal Signaling: Used in skeletal muscle pathway research
Research Applications
Muscle & Skeletal Research
- Muscle growth regulation pathway studies
- Myostatin and activin signaling research
- Musculoskeletal system modeling
Metabolic Research
- Energy metabolism and tissue signaling studies
- Fat and muscle interaction pathway research
- Metabolic signaling investigations
Laboratory & Cellular Research
- Receptor-ligand binding assays
- Signal transduction pathway analysis
- Comparative studies of TGF-β family ligands
Product Specifications
- Product Name: ACE-031 (ActRIIB-IgG1)
- Type: Recombinant fusion protein
- Target: Myostatin / TGF-β superfamily ligands
- Structure: ActRIIB extracellular domain + IgG1 Fc
- Form: Lyophilized (freeze-dried) powder
- Purity: Research grade
Storage & Handling
- Store at -20°C or below for long-term stability
- Reconstitute using sterile laboratory-grade solvent
- Avoid repeated freeze-thaw cycles
- Handle under controlled laboratory conditions
Quality & Production
ACE-031 is produced using recombinant protein expression systems followed by purification and quality control analysis to ensure consistency and suitability for laboratory research applications.
---FAQ (Structured for SEO)
What is ACE-031 used for in research?
ACE-031 is studied in myostatin signaling, TGF-beta pathway research, and musculoskeletal biology models.
What does ACE-031 target?
It targets ligands such as myostatin and activins within the TGF-beta signaling pathway.
Is ACE-031 approved for human use?
No. ACE-031 is strictly intended for laboratory research and is not approved for human consumption or medical use.
Important Disclaimer
- For research purposes only
- Not for human consumption
- Not intended to diagnose, treat, cure, or prevent any disease
- This product is strictly for laboratory research